Version 5.4
Mus musculus Protein: Hdac5
Summary
InnateDB Protein IDBP-531522.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hdac5
Protein Name histone deacetylase 5
Synonyms AI426555; Hdac4; mHDA1; mKIAA0600;
Species Mus musculus
Ensembl Protein ENSMUSP00000118108
InnateDB Gene IDBG-212520 (Hdac5)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 310 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 310 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
GO:0070491 repressing transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002076 osteoblast development
GO:0007507 heart development
GO:0010832 negative regulation of myotube differentiation
GO:0016575 histone deacetylation
GO:0033555 multicellular organismal response to stress
GO:0042220 response to cocaine
GO:0042493 response to drug
GO:0043393 regulation of protein binding
GO:0045668 negative regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048742 regulation of skeletal muscle fiber development
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051153 regulation of striated muscle cell differentiation
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016604 nuclear body
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:1333784
InterPro IPR024643 Histone deacetylase, glutamine rich N-terminal domain
PFAM PF12203
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL B7ZDF6
UniProt Splice Variant
Entrez Gene 15184
UniGene Mm.411525
RefSeq
MGI ID
MGI Symbol Hdac5
OMIM
CCDS
HPRD
IMGT
EMBL AL954730
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca