InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hdac5

Summary

InnateDB Gene

IDBG-212520.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hdac5

Gene Name

histone deacetylase 5

Synonyms

AI426555; Hdac4; mHDA1; mKIAA0600

Species

Mus musculus

Ensembl Gene

ENSMUSG00000008855

Encoded Proteins

IDBP-212522

histone deacetylase 5

IDBP-267273

histone deacetylase 5

IDBP-267275

histone deacetylase 5

IDBP-267277

histone deacetylase 5

IDBP-536734

histone deacetylase 5

IDBP-534678

histone deacetylase 5

IDBP-532092

histone deacetylase 5

IDBP-531522

histone deacetylase 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108840:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:102194432-102230166

Strand

Reverse strand

Band

Transcripts

ENSMUST00000008999	ENSMUSP00000008999
ENSMUST00000107152	ENSMUSP00000102770
ENSMUST00000107151	ENSMUSP00000102769
ENSMUST00000107150	ENSMUSP00000102768
ENSMUST00000136304
ENSMUST00000145540
ENSMUST00000140962	ENSMUSP00000115435
ENSMUST00000124077	ENSMUSP00000116672
ENSMUST00000149087
ENSMUST00000150965
ENSMUST00000137787
ENSMUST00000140481
ENSMUST00000155065
ENSMUST00000126453
ENSMUST00000133651
ENSMUST00000156337	ENSMUSP00000116646
ENSMUST00000131254	ENSMUSP00000118108
ENSMUST00000150683
ENSMUST00000128686
ENSMUST00000125072

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 310 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	310 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0004407	histone deacetylase activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0044212	transcription regulatory region DNA binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002076	osteoblast development
GO:0007507	heart development
GO:0010832	negative regulation of myotube differentiation
GO:0016568	chromatin modification
GO:0016575	histone deacetylation
GO:0033555	multicellular organismal response to stress
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0043393	regulation of protein binding
GO:0045668	negative regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048742	regulation of skeletal muscle fiber development
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051153	regulation of striated muscle cell differentiation
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016604	nuclear body
GO:0043234	protein complex