Version 5.4
Homo sapiens Protein: PUS10
Summary
InnateDB Protein IDBP-53160.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PUS10
Protein Name pseudouridylate synthase 10
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000326003
InnateDB Gene IDBG-53158 (PUS10)
Protein Structure
UniProt Annotation
Function Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death. {ECO:0000269PubMed:14527409, ECO:0000269PubMed:19712588, ECO:0000305}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0009982 pseudouridine synthase activity
Biological Process
GO:0001522 pseudouridine synthesis
GO:0008033 tRNA processing
GO:0009451 RNA modification
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR020103 Pseudouridine synthase, catalytic domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3MIT2
PhosphoSite PhosphoSite-Q3MIT2
TrEMBL C9JNL8
UniProt Splice Variant
Entrez Gene 150962
UniGene
RefSeq NP_653310
HUGO HGNC:26505
OMIM 612787
CCDS CCDS1865
HPRD 08126
IMGT
EMBL AC010733 AK056874 AL832208 BC101680 BC101706 CH471053
GenPept AAI01681 AAI01707 BAB71300 CAI46123 EAX00024

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca