Version 5.4
Homo sapiens Gene: PUS10
Summary
InnateDB Gene IDBG-53158.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PUS10
Gene Name pseudouridylate synthase 10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000162927
Encoded Proteins
IDBP-53160
pseudouridylate synthase 10
IDBP-232574
pseudouridylate synthase 10
IDBP-293139
pseudouridylate synthase 10
IDBP-376995
pseudouridylate synthase 10
IDBP-376997
pseudouridylate synthase 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Pseudouridination, the isomerization of uridine to pseudouridine, is the most common posttranscriptional nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis. Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones, facilitating the correct folding and assembly of tRNAs (McCleverty et al., 2007 [PubMed 17900615]).[supplied by OMIM, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:60940222-61018259
Strand Reverse strand
Band p15
Transcripts
ENST00000316752 ENSP00000326003
ENST00000398658 ENSP00000381651
ENST00000407787 ENSP00000386074
ENST00000421319 ENSP00000402185
ENST00000430495 ENSP00000403880
ENST00000602599
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0009982 pseudouridine synthase activity
Biological Process
GO:0001522 pseudouridine synthesis
GO:0008033 tRNA processing
GO:0009451 RNA modification
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020280
View Gene Order
ENSBTAG00000009694
Not yet available
Cross-References
SwissProt
TrEMBL A8MUL8
UniProt Splice Variant
Entrez Gene 150962
UniGene
RefSeq NM_144709 XM_006711952
HUGO HGNC:26505
OMIM 612787
CCDS CCDS1865
HPRD 08126
IMGT
EMBL AC010733
GenPept
RNA Seq Atlas 150962

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca