Version 5.4
Mus musculus Protein: Axin2
Summary
InnateDB Protein IDBP-531685.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Axin2
Protein Name axin2
Synonyms Axi1; Axil; Conductin;
Species Mus musculus
Ensembl Protein ENSMUSP00000119915
InnateDB Gene IDBG-213782 (Axin2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0070016 armadillo repeat domain binding
GO:0070411 I-SMAD binding
Biological Process
GO:0001756 somitogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0001957 intramembranous ossification
GO:0003139 secondary heart field specification
GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0008219 cell death
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009950 dorsal/ventral axis specification
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010942 positive regulation of cell death
GO:0030111 regulation of Wnt signaling pathway
GO:0030282 bone mineralization
GO:0032423 regulation of mismatch repair
GO:0034613 cellular protein localization
GO:0035412 regulation of catenin import into nucleus
GO:0035414 negative regulation of catenin import into nucleus
GO:0042476 odontogenesis
GO:0043547 positive regulation of GTPase activity
GO:0043570 maintenance of DNA repeat elements
GO:0045668 negative regulation of osteoblast differentiation
GO:0048255 mRNA stabilization
GO:0061181 regulation of chondrocyte development
GO:0070602 regulation of centromeric sister chromatid cohesion
GO:0071407 cellular response to organic cyclic compound
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090244 Wnt signaling pathway involved in somitogenesis
Cellular Component
GO:0005634 nucleus
GO:0005813 centrosome
GO:0005881 cytoplasmic microtubule
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0014069 postsynaptic density
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030877 beta-catenin destruction complex
Protein Structure and Domains
PDB ID MGI:1270862
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A2ABQ7
UniProt Splice Variant
Entrez Gene 12006
UniGene Mm.71710
RefSeq
MGI ID
MGI Symbol Axin2
OMIM
CCDS
HPRD
IMGT
EMBL AL662893
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca