InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CEACAM5

Summary

InnateDB Protein

IDBP-53176.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CEACAM5

Protein Name

carcinoembryonic antigen-related cell adhesion molecule 5

Synonyms

CD66e; CEA;

Species

Homo sapiens

Ensembl Protein

ENSP00000221992

InnateDB Gene

IDBG-53174 (CEACAM5)

Protein Structure

UniProt Annotation

Function

Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. {ECO:0000269PubMed:10864933}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:10864933, ECO:0000269PubMed:18086185}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:10864933, ECO:0000269PubMed:18086185}.

Disease Associations

Tissue Specificity

Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0034235	GPI anchor binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0010832	negative regulation of myotube differentiation
GO:0034109	homotypic cell-cell adhesion
GO:0043066	negative regulation of apoptotic process
GO:2000811	negative regulation of anoikis

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016323	basolateral plasma membrane
GO:0031225	anchored component of membrane
GO:0070062	extracellular vesicular exosome
GO:0071575	integral component of external side of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P06731