Version 5.4
Mus musculus Protein: Ano2
Summary
InnateDB Protein IDBP-531816.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ano2
Protein Name anoctamin 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000125303
InnateDB Gene IDBG-190085 (Ano2)
Protein Structure
UniProt Annotation
Function Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. {ECO:0000269PubMed:19474308, ECO:0000269PubMed:19475416, ECO:0000269PubMed:19561302, ECO:0000269PubMed:21890523, ECO:0000269PubMed:22075693}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:19474308, ECO:0000269PubMed:19561302}; Multi-pass membrane protein {ECO:0000269PubMed:19474308, ECO:0000269PubMed:19561302}.
Disease Associations
Tissue Specificity Expressed in retina, especially in the photoreceptor synaptic terminals, and in olfactory epithelium, particularly in sensory neurons (OSNs) and cilia (at protein level). Also observed in retinal pigment epithelium (RPE), olfactory bulb, brain, and cortex. {ECO:0000269PubMed:19474308, ECO:0000269PubMed:19561302, ECO:0000269PubMed:20056604}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005229 intracellular calcium activated chloride channel activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006821 chloride transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0031513 nonmotile primary cilium
GO:0034707 chloride channel complex
Protein Structure and Domains
PDB ID MGI:2387214
InterPro IPR007632 Anoctamin
PFAM PF04547
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CFW1
PhosphoSite PhosphoSite-Q8CFW1
TrEMBL M1H0B0
UniProt Splice Variant
Entrez Gene 243634
UniGene Mm.333398
RefSeq NP_705817
MGI ID
MGI Symbol Ano2
OMIM
CCDS CCDS39643
HPRD
IMGT
EMBL AC122284 AC153372 AC153578 AC153868 AC155837 AK044763 BC033409 FJ384096 KC164759
GenPept AAH33409 ACL36051 AGE31681 BAC32073

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca