InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slirp

Summary

InnateDB Protein

IDBP-531860.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slirp

Protein Name

RIKEN cDNA 1810035L17 gene

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124174

InnateDB Gene

IDBG-160379 (Slirp)

Protein Structure

UniProt Annotation

Function

RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding

Biological Process

GO:0000961	negative regulation of mitochondrial RNA catabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007286	spermatid development
GO:0007338	single fertilization
GO:0030317	sperm motility
GO:0070584	mitochondrion morphogenesis

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0030529	ribonucleoprotein complex
GO:0036126	sperm flagellum
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1916394

InterPro

IPR000504 RNA recognition motif domain

PFAM

PF00076

PRINTS

PIRSF

SMART

SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D8T7

PhosphoSite

PhosphoSite-Q9D8T7

TrEMBL

UniProt Splice Variant

Entrez Gene

380773

UniGene

RefSeq

MGI ID

MGI Symbol

Slirp

OMIM

CCDS

HPRD

IMGT

EMBL

AJ293625 AK007699 BC100567

GenPept

AAI00568 BAB25197 CAC34586