Version 5.4
Homo sapiens Protein: PYY
Summary
InnateDB Protein IDBP-53194.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PYY
Protein Name peptide YY
Synonyms PYY-I; PYY1;
Species Homo sapiens
Ensembl Protein ENSP00000353198
InnateDB Gene IDBG-53192 (PYY)
Protein Structure
UniProt Annotation
Function This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding
Biological Process
GO:0006928 cellular component movement
GO:0007010 cytoskeleton organization
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007586 digestion
GO:0007631 feeding behavior
GO:0008283 cell proliferation
GO:0042755 eating behavior
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR001955 Pancreatic hormone-like
PFAM PF00159
PRINTS PR00278
PIRSF
SMART SM00309
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P10082
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 5697
UniGene
RefSeq NP_004151
HUGO HGNC:9748
OMIM 600781
CCDS CCDS32662
HPRD 02869
IMGT
EMBL AC007993 BC041057 CR542129 D13897 D13899 D13902 L25648
GenPept AAA36433 AAH41057 BAA02997 BAA02998 BAA03000 BAA03002 CAG46926

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca