InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zfat

Summary

InnateDB Protein

IDBP-531967.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfat

Protein Name

zinc finger and AT hook domain containing

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125732

InnateDB Gene

IDBG-147216 (Zfat)

Protein Structure

UniProt Annotation

Function

May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated. {ECO:0000269PubMed:18329245}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18329245}. Cytoplasm, cytosol {ECO:0000269PubMed:18329245}.

Disease Associations

Tissue Specificity

Detected in spleen and thymus but not in liver, muscle, heart, kidney, brain, bone marrow or pancreas. Expressed in CD19+, CD4+ and CD8+ lymphocytes but not in CD11b+ lymphocytes or peritoneal macrophages (at protein level). {ECO:0000269PubMed:18329245}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006351	transcription, DNA-templated
GO:0030097	hemopoiesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060712	spongiotrophoblast layer development