InnateDB Protein
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IDBP-532015.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Slirp
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Protein Name
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RIKEN cDNA 1810035L17 gene
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000125341
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InnateDB Gene
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IDBG-160379 (Slirp)
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Protein Structure
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Function |
RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
30 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1916394
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D8T7
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PhosphoSite |
PhosphoSite-Q9D8T7
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TrEMBL |
Q14AR0
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UniProt Splice Variant |
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Entrez Gene |
380773
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UniGene |
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RefSeq |
NP_081234
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MGI ID |
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MGI Symbol |
Slirp
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OMIM |
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CCDS |
CCDS36503
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HPRD |
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IMGT |
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EMBL |
AJ293625
AK007699
BC100567
BC116739
BC116741
CH466590
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GenPept |
AAI00568
AAI16740
AAI16742
BAB25197
CAC34586
EDL02952
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