InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Otub1

Summary

InnateDB Protein

IDBP-532205.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Otub1

Protein Name

OTU domain, ubiquitin aldehyde binding 1

Synonyms

AI850305;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115195

InnateDB Gene

IDBG-138319 (Otub1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	61 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0008242	omega peptidase activity
GO:0019784	NEDD8-specific protease activity
GO:0031625	ubiquitin protein ligase binding
GO:0043130	ubiquitin binding

Biological Process

GO:0006508	proteolysis
GO:0006974	cellular response to DNA damage stimulus
GO:0019538	protein metabolic process
GO:0071108	protein K48-linked deubiquitination
GO:1901315	negative regulation of histone H2A K63-linked ubiquitination
GO:2000780	negative regulation of double-strand break repair

Cellular Component

Protein Structure and Domains

PDB ID

MGI:2147616

InterPro

IPR003323 Ovarian tumour, otubain
IPR016615 Ubiquitin thioesterase Otubain
IPR019400 Peptidase C65, otubain

PFAM

PF02338
PF10275

PRINTS

PIRSF

PIRSF013503

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3Z7K0

UniProt Splice Variant

Entrez Gene

107260

UniGene

Mm.440389

RefSeq

MGI ID

MGI Symbol

Otub1

OMIM

CCDS

HPRD

IMGT

EMBL

AC140307

GenPept