InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slx1b

Summary

InnateDB Protein

IDBP-532244.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slx1b

Protein Name

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)

Synonyms

1110030E23Rik; 2410170E21Rik; 4833422P03Rik; AI853643; Giyd1; Giyd2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118182

InnateDB Gene

IDBG-209733 (Slx1b)

Protein Structure

UniProt Annotation

Function

Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. {ECO:0000255HAMAP-Rule:MF_03100}.

Subcellular Localization

Nucleus {ECO:0000255HAMAP-Rule:MF_03100}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008821	crossover junction endodeoxyribonuclease activity
GO:0017108	5'-flap endonuclease activity
GO:0046872	metal ion binding

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0006310	DNA recombination

Cellular Component

GO:0033557

Slx1-Slx4 complex

Protein Structure and Domains

PDB ID

MGI:1915220

InterPro

IPR000305 GIY-YIG nuclease superfamily
IPR011011 Zinc finger, FYVE/PHD-type

PFAM

PF01541

PRINTS

PIRSF

SMART

SM00465

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BX32

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

75764

UniGene

Mm.280573

RefSeq

NP_083696

MGI ID

MGI Symbol

Slx1b

OMIM

CCDS

CCDS21838

HPRD

IMGT

EMBL

AK014753 AK049139 BC145688

GenPept

AAI45689 BAB29533 BAC33566