InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc4a4

Summary

InnateDB Protein

IDBP-532534.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc4a4

Protein Name

solute carrier family 4 (anion exchanger), member 4

Synonyms

AI835705; NBC; NBC1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119325

InnateDB Gene

IDBG-177669 (Slc4a4)

Protein Structure

UniProt Annotation

Function

Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.

Subcellular Localization

Basolateral cell membrane {ECO:0000269PubMed:11171615}; Multi-pass membrane protein {ECO:0000269PubMed:11171615}.

Disease Associations

Tissue Specificity

Isoform 1 is specifically expressed in pancreatic ducts and acini. Also expressed in parotid acinar cells and in the colonic crypts. {ECO:0000269PubMed:11171615, ECO:0000269PubMed:12388213, ECO:0000269PubMed:12727194, ECO:0000269PubMed:9651366}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005452	inorganic anion exchanger activity
GO:0005515	protein binding
GO:0008509	anion transmembrane transporter activity
GO:0008510	sodium:bicarbonate symporter activity

Biological Process

GO:0006810	transport
GO:0006814	sodium ion transport
GO:0006820	anion transport
GO:0006885	regulation of pH
GO:0015701	bicarbonate transport
GO:0035725	sodium ion transmembrane transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane

Protein Structure and Domains

PDB ID

MGI:1927555

InterPro

IPR003020 Bicarbonate transporter, eukaryotic
IPR003024 Sodium bicarbonate cotransporter
IPR011531 Bicarbonate transporter, C-terminal
IPR013769 Band 3 cytoplasmic domain
IPR016152 Phosphotransferase/anion transporter

PFAM

PF00955
PF07565

PRINTS

PR01231
PR01232

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88343