InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Flt3l

Summary

InnateDB Protein

IDBP-532819.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Flt3l

Protein Name

FMS-like tyrosine kinase 3 ligand

Synonyms

Flt3lg; Ly72L;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000123506

InnateDB Gene

IDBG-488510 (Flt3l)

Protein Structure

UniProt Annotation

Function

Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.Isoform 3: Secreted. Note=Biologically active.Isoform 4: Secreted. Note=Inactive.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0030971	receptor tyrosine kinase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0008284	positive regulation of cell proliferation
GO:0030098	lymphocyte differentiation
GO:0032825	positive regulation of natural killer cell differentiation
GO:0035162	embryonic hemopoiesis

Cellular Component

GO:0005615	extracellular space
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031233	intrinsic to external side of plasma membrane