Version 5.4
Mus musculus Gene: Flt3l
Summary
InnateDB Gene IDBG-488510.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Flt3l
Gene Name FMS-like tyrosine kinase 3 ligand
Synonyms Flt3lg; Ly72L
Species Mus musculus
Ensembl Gene ENSMUSG00000089989
Encoded Proteins
IDBP-181669
FMS-like tyrosine kinase 3 ligand
IDBP-538647
FMS-like tyrosine kinase 3 ligand
IDBP-532819
FMS-like tyrosine kinase 3 ligand
IDBP-532212
FMS-like tyrosine kinase 3 ligand
IDBP-533420
FMS-like tyrosine kinase 3 ligand
IDBP-532462
FMS-like tyrosine kinase 3 ligand
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 7:45131188-45136432
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000085377 ENSMUSP00000082492
ENSMUST00000128778 ENSMUSP00000119070
ENSMUST00000146760 ENSMUSP00000123506
ENSMUST00000134065
ENSMUST00000123381 ENSMUSP00000115222
ENSMUST00000126371
ENSMUST00000125500 ENSMUSP00000119175
ENSMUST00000130628 ENSMUSP00000118193
ENSMUST00000150673
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0016301 kinase activity
GO:0030971 receptor tyrosine kinase binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0008284 positive regulation of cell proliferation
GO:0016310 phosphorylation
GO:0030098 lymphocyte differentiation
GO:0032825 positive regulation of natural killer cell differentiation
GO:0035162 embryonic hemopoiesis
Cellular Component
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031233 intrinsic to external side of plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04640
Hematopoietic cell lineage pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt P49772
TrEMBL
UniProt Splice Variant
Entrez Gene 14256
UniGene Mm.1658
RefSeq NM_013520 XM_006540609 XM_006540610
OMIM
CCDS CCDS39948
HPRD
IMGT
MGI ID MGI:95560
MGI Symbol Flt3l
EMBL AK020105 L23636 S76459 S76461 S76464 U04807 U29875 U44024
GenPept AAA18000 AAA39436 AAA90951 AAA90952 AAA93306 AAA93307 AAB33069 AAB33070 AAB33071 BAB31997
RNA Seq Atlas 14256

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca