InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fhit

Summary

InnateDB Protein

IDBP-532871.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fhit

Protein Name

fragile histidine triad gene

Synonyms

AW045638; Fra14A2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000123874

InnateDB Gene

IDBG-132104 (Fhit)

Protein Structure

UniProt Annotation

Function

Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity (By similarity). Functions as tumor suppressor. {ECO:0000250, ECO:0000269PubMed:10758156, ECO:0000269PubMed:11517343}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9699672}.

Disease Associations

Tissue Specificity

Expressed in heart, brain, lung and skeletal muscle. Particularly strong expression in liver, testis and kidney, where it is confined to the tubular epithelium. {ECO:0000269PubMed:9671749, ECO:0000269PubMed:9699672}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0016787	hydrolase activity
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding
GO:0047710	bis(5'-adenosyl)-triphosphatase activity

Biological Process

GO:0006163	purine nucleotide metabolic process
GO:0006260	DNA replication
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009117	nucleotide metabolic process
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator