Version 5.4
Mus musculus Gene: Fhit
Summary
InnateDB Gene IDBG-132104.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fhit
Gene Name fragile histidine triad gene
Synonyms AW045638; Fra14A2
Species Mus musculus
Ensembl Gene ENSMUSG00000060579
Encoded Proteins
IDBP-532871
fragile histidine triad gene
IDBP-541809
fragile histidine triad gene
IDBP-535793
fragile histidine triad gene
IDBP-535269
fragile histidine triad gene
IDBP-542775
fragile histidine triad gene
IDBP-537722
fragile histidine triad gene
IDBP-717508
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000189283:
This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
This gene, a member of the histidine triad gene family, encodes a diadenosine 5\',5\'\'\'-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:9550092-11162035
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000161302 ENSMUSP00000123874
ENSMUST00000160340 ENSMUSP00000124017
ENSMUST00000162278 ENSMUSP00000124073
ENSMUST00000161895 ENSMUSP00000124957
ENSMUST00000161179
ENSMUST00000162817 ENSMUSP00000124500
ENSMUST00000160956 ENSMUSP00000123820
ENSMUST00000179394 ENSMUSP00000136011
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0047710 bis(5'-adenosyl)-triphosphatase activity
Biological Process
GO:0006163 purine nucleotide metabolic process
GO:0006260 DNA replication
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009117 nucleotide metabolic process
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000189283
View Gene Order
ENSBTAG00000014418
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05222
Small cell lung cancer pathway
mmu00230
Purine metabolism pathway
mmu05223
Non-small cell lung cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05223
Non-small cell lung cancer pathway
hsa00230
Purine metabolism pathway
hsa05222
Small cell lung cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.397619 Mm.441926
RefSeq NM_010210 XM_006517923 XM_006517924 XM_006517925 XM_006517927
OMIM
CCDS CCDS49400
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca