InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HDAC5

Summary

InnateDB Protein

IDBP-53299.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HDAC5

Protein Name

histone deacetylase 5

Synonyms

HD5; NY-CO-9;

Species

Homo sapiens

Ensembl Protein

ENSP00000337290

InnateDB Gene

IDBG-53295 (HDAC5)

Protein Structure

UniProt Annotation

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269PubMed:24413532}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 368 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	368 [view]
Protein-Protein	365 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004407	histone deacetylase activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0070491	repressing transcription factor binding
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006325	chromatin organization
GO:0006338	chromatin remodeling
GO:0006342	chromatin silencing
GO:0006351	transcription, DNA-templated
GO:0006954	inflammatory response
GO:0007219	Notch signaling pathway
GO:0010830	regulation of myotube differentiation
GO:0010832	negative regulation of myotube differentiation
GO:0016568	chromatin modification
GO:0016575	histone deacetylation
GO:0030183	B cell differentiation
GO:0032869	cellular response to insulin stimulus
GO:0042113	B cell activation
GO:0043393	regulation of protein binding
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus

Protein Structure and Domains

PDB ID

InterPro

IPR000286 Histone deacetylase superfamily
IPR017320 Histone deacetylase class II, eukaryotic
IPR023801 Histone deacetylase domain
IPR024643 Histone deacetylase, glutamine rich N-terminal domain

PFAM

PF00850
PF12203

PRINTS

PR01270

PIRSF

PIRSF037911

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt