InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tbc1d4

Summary

InnateDB Protein

IDBP-533044.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tbc1d4

Protein Name

TBC1 domain family, member 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124909

InnateDB Gene

IDBG-184270 (Tbc1d4)

Protein Structure

UniProt Annotation

Function

May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11994271}. Note=Cytoplasmic perinuclear. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed, including in pancreatic beta cells. {ECO:0000269PubMed:11994271, ECO:0000269PubMed:18276765}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005097	Rab GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0016192	vesicle-mediated transport
GO:0032313	regulation of Rab GTPase activity
GO:0032851	positive regulation of Rab GTPase activity
GO:0032869	cellular response to insulin stimulus