InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sucla2

Summary

InnateDB Protein

IDBP-533059.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sucla2

Protein Name

succinate-Coenzyme A ligase, ADP-forming, beta subunit

Synonyms

4930547K18Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000123765

InnateDB Gene

IDBG-180147 (Sucla2)

Protein Structure

UniProt Annotation

Function

Catalyzes the ATP-dependent ligation of succinate and CoA to form succinyl-CoA. {ECO:0000250}.

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004774	succinate-CoA ligase activity
GO:0004775	succinate-CoA ligase (ADP-forming) activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006104	succinyl-CoA metabolic process
GO:0006105	succinate metabolic process
GO:0008152	metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1306775

InterPro

IPR005809 Succinyl-CoA synthetase, beta subunit
IPR005811 ATP-citrate lyase/succinyl-CoA ligase
IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
IPR016102 Succinyl-CoA synthetase-like

PFAM

PF00549
PF08442

PRINTS

PIRSF

PIRSF001554

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z2I9