Version 5.4
Mus musculus Gene: Sucla2
Summary
InnateDB Gene IDBG-180147.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sucla2
Gene Name succinate-Coenzyme A ligase, ADP-forming, beta subunit
Synonyms 4930547K18Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000022110
Encoded Proteins
IDBP-180149
succinate-Coenzyme A ligase, ADP-forming, beta subunit
IDBP-533323
succinate-Coenzyme A ligase, ADP-forming, beta subunit
IDBP-533059
succinate-Coenzyme A ligase, ADP-forming, beta subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136143:
Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:73525319-73596142
Strand Forward strand
Band D3
Transcripts
ENSMUST00000022706 ENSMUSP00000022706
ENSMUST00000162691 ENSMUSP00000123898
ENSMUST00000162723
ENSMUST00000160507 ENSMUSP00000123765
ENSMUST00000161829
ENSMUST00000161082
ENSMUST00000159165
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004774 succinate-CoA ligase activity
GO:0004775 succinate-CoA ligase (ADP-forming) activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006104 succinyl-CoA metabolic process
GO:0006105 succinate metabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000136143
View Gene Order
ENSBTAG00000006759
Not yet available
Pathways
NETPATH
REACTOME
REACT_189162
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_188937
Metabolism pathway
REACT_241308
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_249033
Citric acid cycle (TCA cycle) pathway
KEGG
mmu00020
Citrate cycle (TCA cycle) pathway
mmu00640
Propanoate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1785
Citric acid cycle (TCA cycle) pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa00020
Citrate cycle (TCA cycle) pathway
hsa00640
Propanoate metabolism pathway
INOH
INOH website
Citrate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.38951 Mm.393800 Mm.443501 Mm.488443
RefSeq NM_011506 XM_006518757 XM_006518758
OMIM
CCDS CCDS27271
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca