InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Insig2

Summary

InnateDB Protein

IDBP-533147.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Insig2

Protein Name

insulin induced gene 2

Synonyms

2900053I11Rik; C730043J18Rik; Insig-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000123747

InnateDB Gene

IDBG-188177 (Insig2)

Protein Structure

UniProt Annotation

Function

Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. {ECO:0000269PubMed:12242332, ECO:0000269PubMed:12624180}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in liver, testis, kidney, spleen, intestine, brain and adrenal gland. {ECO:0000269PubMed:12624180}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0006641	triglyceride metabolic process
GO:0006695	cholesterol biosynthetic process
GO:0006991	response to sterol depletion
GO:0008203	cholesterol metabolic process
GO:0010894	negative regulation of steroid biosynthetic process
GO:0016126	sterol biosynthetic process
GO:0032868	response to insulin
GO:0032933	SREBP signaling pathway
GO:0042472	inner ear morphogenesis
GO:0042474	middle ear morphogenesis
GO:0045717	negative regulation of fatty acid biosynthetic process
GO:0060021	palate development
GO:0060363	cranial suture morphogenesis
GO:0070542	response to fatty acid