Version 5.4
Mus musculus Gene: Insig2
Summary
InnateDB Gene IDBG-188177.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Insig2
Gene Name insulin induced gene 2
Synonyms 2900053I11Rik; C730043J18Rik; Insig-2
Species Mus musculus
Ensembl Gene ENSMUSG00000003721
Encoded Proteins
IDBP-188179
insulin induced gene 2
IDBP-188181
insulin induced gene 2
IDBP-533147
insulin induced gene 2
IDBP-534270
insulin induced gene 2
IDBP-539166
insulin induced gene 2
IDBP-537826
insulin induced gene 2
IDBP-539106
insulin induced gene 2
IDBP-540637
insulin induced gene 2
IDBP-540627
insulin induced gene 2
IDBP-533824
insulin induced gene 2
IDBP-788430
insulin induced gene 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125629:
The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:121304353-121332589
Strand Reverse strand
Band E2.3
Transcripts
ENSMUST00000003818 ENSMUSP00000003818
ENSMUST00000071064 ENSMUSP00000065485
ENSMUST00000160968 ENSMUSP00000123747
ENSMUST00000159085 ENSMUSP00000124345
ENSMUST00000159528
ENSMUST00000160688 ENSMUSP00000123702
ENSMUST00000159192
ENSMUST00000162582 ENSMUSP00000125046
ENSMUST00000162790 ENSMUSP00000124697
ENSMUST00000162019
ENSMUST00000159125 ENSMUSP00000123729
ENSMUST00000161818 ENSMUSP00000123993
ENSMUST00000161068 ENSMUSP00000125216
ENSMUST00000186915 ENSMUSP00000140292
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
Biological Process
GO:0006641 triglyceride metabolic process
GO:0006695 cholesterol biosynthetic process
GO:0006991 response to sterol depletion
GO:0008203 cholesterol metabolic process
GO:0010894 negative regulation of steroid biosynthetic process
GO:0016126 sterol biosynthetic process
GO:0032868 response to insulin
GO:0032933 SREBP signaling pathway
GO:0033993 response to lipid
GO:0042472 inner ear morphogenesis
GO:0042474 middle ear morphogenesis
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0060021 palate development
GO:0060363 cranial suture morphogenesis
GO:0070542 response to fatty acid
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0032937 SREBP-SCAP-Insig complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000125629
View Gene Order
ENSBTAG00000002112
Not yet available
Pathways
NETPATH
REACTOME
REACT_198968
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 72999
UniGene
RefSeq NM_001271531 NM_133748 NM_178082 XM_006529889 XM_006529892
OMIM
CCDS CCDS15236
HPRD
IMGT
MGI ID MGI:1920249
MGI Symbol Insig2
EMBL
GenPept
RNA Seq Atlas 72999

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca