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InnateDB Protein
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IDBP-533163.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ubr4
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Protein Name
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ubiquitin protein ligase E3 component n-recognin 4
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Synonyms
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1810009A16Rik; A930005E13Rik; D930005K06Rik; Gm1032; Gm1666; mKIAA0462; N28143; p600; RBAF600; Zubr1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000114947
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InnateDB Gene
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IDBG-200435 (Ubr4)
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Protein Structure
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| Function |
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. {ECO:0000269PubMed:16055722}.
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| Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Note=Concentrates at the leading edge of membrane structures involved in actin motility. {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
Widely expressed in adult and embryonic stages with highest levels in testis and brain. {ECO:0000269PubMed:16055722}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
5
[view]
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| Protein-Protein |
5
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
34 [view]
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| PDB ID |
MGI:1916366
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-A2AN08
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| TrEMBL |
Z4YLP1
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| UniProt Splice Variant |
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| Entrez Gene |
69116
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| UniGene |
Mm.420835
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Ubr4
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AL807811
AL807833
AL929419
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| GenPept |
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Version 5.4