Version 5.4
Mus musculus Gene: Ubr4
Summary
InnateDB Gene IDBG-200435.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ubr4
Gene Name ubiquitin protein ligase E3 component n-recognin 4
Synonyms 1810009A16Rik; A930005E13Rik; D930005K06Rik; Gm1032; Gm1666; mKIAA0462; N28143; p600; RBAF600; Zubr1
Species Mus musculus
Ensembl Gene ENSMUSG00000066036
Encoded Proteins
IDBP-200443
ubiquitin protein ligase E3 component n-recognin 4
IDBP-536288
ubiquitin protein ligase E3 component n-recognin 4
IDBP-542139
ubiquitin protein ligase E3 component n-recognin 4
IDBP-533163
ubiquitin protein ligase E3 component n-recognin 4
IDBP-625857
ubiquitin protein ligase E3 component n-recognin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127481:
The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:139352609-139489588
Strand Forward strand
Band D3
Transcripts
ENSMUST00000097822 ENSMUSP00000095433
ENSMUST00000147999 ENSMUSP00000117419
ENSMUST00000133220
ENSMUST00000129949 ENSMUSP00000115711
ENSMUST00000149995
ENSMUST00000129779 ENSMUSP00000114947
ENSMUST00000136230
ENSMUST00000145273
ENSMUST00000145659
ENSMUST00000141327
ENSMUST00000135534
ENSMUST00000165860 ENSMUSP00000125800
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000127481
View Gene Order
ENSBTAG00000015240
Not yet available
Pathways
NETPATH
REACTOME
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_230745
Immune System pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_229531
Adaptive Immune System pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Z4YLP1
UniProt Splice Variant
Entrez Gene 69116
UniGene Mm.271956 Mm.410718 Mm.420835
RefSeq NM_001160319
OMIM
CCDS CCDS51340
HPRD
IMGT
MGI ID MGI:1916366
MGI Symbol Ubr4
EMBL AL807811 AL807833 AL929419
GenPept
RNA Seq Atlas 69116

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca