InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vta1

Summary

InnateDB Protein

IDBP-533240.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vta1

Protein Name

Vps20-associated 1 homolog (S. cerevisiae)

Synonyms

1110001D18Rik; 1110059P08Rik; AU040813; C85340; LIP5; SBP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119829

InnateDB Gene

IDBG-134675 (Vta1)

Protein Structure

UniProt Annotation

Function

Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies (By similarity). Involved in the sorting and down-regulation of EGFR. {ECO:0000250, ECO:0000269PubMed:15173323}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15173323}. Endosome membrane {ECO:0000269PubMed:15173323}; Peripheral membrane protein {ECO:0000269PubMed:15173323}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in brain, liver, kidney, spleen, lung and heart (at protein level). {ECO:0000269PubMed:15173323}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0015031

protein transport

Cellular Component

GO:0005737	cytoplasm
GO:0010008	endosome membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1913451

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CR26

PhosphoSite

PhosphoSite-Q9CR26

TrEMBL

UniProt Splice Variant

Entrez Gene

66201

UniGene

RefSeq

NP_079694

MGI ID

MGI Symbol

Vta1

OMIM

CCDS

CCDS23705

HPRD

IMGT

EMBL

AK002611 AK009227 BC026752

GenPept

AAH26752 BAB22228 BAB26150