InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Msi1

Summary

InnateDB Protein

IDBP-533289.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Msi1

Protein Name

Musashi homolog 1(Drosophila)

Synonyms

m-Msi-1; Msi1h; Musahi1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120516

InnateDB Gene

IDBG-193777 (Msi1)

Protein Structure

UniProt Annotation

Function

RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'- GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'- [GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system. {ECO:0000269PubMed:11359897, ECO:0000269PubMed:12407178}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in olfactory bulb, brain stem, small intestine, and at low levels in brain cortex, hippocampus and ovary. Detected in neural progenitor cells, including neural stem cells. {ECO:0000269PubMed:8660864}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003727	single-stranded RNA binding
GO:0008266	poly(U) RNA binding
GO:0044822	poly(A) RNA binding