InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vps51

Summary

InnateDB Protein

IDBP-533350.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vps51

Protein Name

RIKEN cDNA 1110014N23 gene

Synonyms

1110014N23Rik; 3110057M17Rik; AI837850; Ffr;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000123994

InnateDB Gene

IDBG-134384 (Vps51)

Protein Structure

UniProt Annotation

Function

Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy (By similarity). VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus, trans-Golgi network {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0006869	lipid transport
GO:0006914	autophagy
GO:0007067	mitotic nuclear division
GO:0015031	protein transport
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000938	GARP complex
GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0017119	Golgi transport complex

Protein Structure and Domains

PDB ID

MGI:1915755

InterPro

IPR007255 Conserved oligomeric Golgi complex subunit 8
IPR009361 RZZ complex, subunit Zw10
IPR016159 Cullin repeat-like-containing domain
IPR019515 Vacuolar protein sorting-associated protein 54
IPR024602 Conserved oligomeric Golgi complex, subunit 2, N-terminal

PFAM

PF04124
PF06248
PF10475
PF06148

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3UVL4

PhosphoSite