InnateDB Protein
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IDBP-533420.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Flt3l
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Protein Name
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FMS-like tyrosine kinase 3 ligand
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Synonyms
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Flt3lg; Ly72L;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000119175
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InnateDB Gene
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IDBG-488510 (Flt3l)
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Protein Structure
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Function |
Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.
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Subcellular Localization |
Cell membrane; Single-pass type I membrane protein.Isoform 3: Secreted. Note=Biologically active.Isoform 4: Secreted. Note=Inactive.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0001934
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positive regulation of protein phosphorylation
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GO:0008284
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positive regulation of cell proliferation
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GO:0030098
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lymphocyte differentiation
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GO:0032825
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positive regulation of natural killer cell differentiation
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GO:0035162
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embryonic hemopoiesis
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Cellular Component |
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PDB ID |
MGI:95560
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InterPro |
IPR004213
Flt3 ligand
IPR009079
Four-helical cytokine-like, core
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PFAM |
PF02947
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P49772
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
14256
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UniGene |
Mm.1658
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RefSeq |
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MGI ID |
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MGI Symbol |
Flt3l
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK020105
L23636
S76459
S76461
S76464
U04807
U29875
U44024
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GenPept |
AAA18000
AAA39436
AAA90951
AAA90952
AAA93306
AAA93307
AAB33069
AAB33070
AAB33071
BAB31997
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