InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plch2

Summary

InnateDB Protein

IDBP-533436.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plch2

Protein Name

phospholipase C, eta 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122704

InnateDB Gene

IDBG-207301 (Plch2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0035556	intracellular signal transduction
GO:0046488	phosphatidylinositol metabolic process

Cellular Component

GO:0005886

plasma membrane

Protein Structure and Domains

PDB ID

MGI:2443078

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR002048 EF-hand domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM