InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pde8b

Summary

InnateDB Protein

IDBP-533486.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde8b

Protein Name

phosphodiesterase 8B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124068

InnateDB Gene

IDBG-173643 (Pde8b)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000156	two-component response regulator activity
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0046872	metal ion binding

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0035556	intracellular signal transduction
GO:0046676	negative regulation of insulin secretion
GO:0090032	negative regulation of steroid hormone biosynthetic process

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:2443999

InterPro

IPR001789 Signal transduction response regulator, receiver domain
IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR011006 CheY-like superfamily
IPR013938 3\'5\'-cyclic nucleotide phosphodiesterase PDE8
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00072
PF00233
PF08629

PRINTS

PR00387

PIRSF

SMART

SM00448
SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt