InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nebl

Summary

InnateDB Protein

IDBP-533603.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nebl

Protein Name

nebulette

Synonyms

1200007O21Rik; A630080F05Rik; BB140644; D830029A09Rik; Lnebl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122024

InnateDB Gene

IDBG-139017 (Nebl)

Protein Structure

UniProt Annotation

Function

Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005523	tropomyosin binding
GO:0008092	cytoskeletal protein binding
GO:0031005	filamin binding
GO:0051015	actin filament binding

Biological Process

GO:0071691

cardiac muscle thin filament assembly

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0030018	Z disc
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1921353

InterPro

IPR000900 Nebulin repeat

PFAM

PF00880

PRINTS

PIRSF

SMART

SM00227

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0II04

PhosphoSite

PhosphoSite-

TrEMBL

Q0VD73

UniProt Splice Variant

Entrez Gene

74103

UniGene

Mm.462602

RefSeq

MGI ID

MGI Symbol

Nebl

OMIM

CCDS

HPRD

IMGT

EMBL

AL772218 AL845498 AL935297 AL954131 BC119802 BC122879

GenPept

AAI19803 AAI22880 CAX16131