Version 5.4
Mus musculus Gene: Nebl
Summary
InnateDB Gene IDBG-139017.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nebl
Gene Name nebulette
Synonyms 1200007O21Rik; A630080F05Rik; BB140644; D830029A09Rik; Lnebl
Species Mus musculus
Ensembl Gene ENSMUSG00000053702
Encoded Proteins
IDBP-139019
nebulette
IDBP-540191
nebulette
IDBP-539459
nebulette
IDBP-533247
nebulette
IDBP-533603
nebulette
IDBP-539735
nebulette
IDBP-718527
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078114:
This gene encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:17343909-17731464
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000028080 ENSMUSP00000028080
ENSMUST00000124270 ENSMUSP00000117805
ENSMUST00000138241
ENSMUST00000124611 ENSMUSP00000116065
ENSMUST00000150194
ENSMUST00000137253
ENSMUST00000127912
ENSMUST00000131957 ENSMUSP00000118525
ENSMUST00000132418 ENSMUSP00000122024
ENSMUST00000145492 ENSMUSP00000121313
ENSMUST00000145545
ENSMUST00000130725
ENSMUST00000177966 ENSMUSP00000137567
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005523 tropomyosin binding
GO:0008092 cytoskeletal protein binding
GO:0008270 zinc ion binding
GO:0031005 filamin binding
GO:0051015 actin filament binding
Biological Process
GO:0071691 cardiac muscle thin filament assembly
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0030018 Z disc
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000078114
View Gene Order
ENSBTAG00000013339
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.120298 Mm.462602
RefSeq NM_028757 XM_006497557
OMIM
CCDS CCDS15706
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca