Version 5.4
Mus musculus Protein: Acaca
Summary
InnateDB Protein IDBP-533642.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acaca
Protein Name acetyl-Coenzyme A carboxylase alpha
Synonyms A530025K05Rik; Acac; Acc1; Gm738;
Species Mus musculus
Ensembl Protein ENSMUSP00000117972
InnateDB Gene IDBG-206042 (Acaca)
Protein Structure
UniProt Annotation
Function Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (By similarity). {ECO:0000250UniProtKB:P11497}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12360400, ECO:0000269PubMed:20952656}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003989 acetyl-CoA carboxylase activity
GO:0004075 biotin carboxylase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0001894 tissue homeostasis
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0044268 multicellular organismal protein metabolic process
GO:0055088 lipid homeostasis
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:108451
InterPro IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR011764 Biotin carboxylation domain
IPR016185 Pre-ATP-grasp domain
PFAM PF00289
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q5SWU9
TrEMBL V9GWS1
UniProt Splice Variant
Entrez Gene 107476
UniGene Mm.31374
RefSeq
MGI ID
MGI Symbol Acaca
OMIM
CCDS
HPRD
IMGT
EMBL AL596252 AL596447
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca