Version 5.4
Mus musculus Protein: Slc39a14
Summary
InnateDB Protein IDBP-533681.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc39a14
Protein Name solute carrier family 39 (zinc transporter), member 14
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000119040
InnateDB Gene IDBG-178315 (Slc39a14)
Protein Structure
UniProt Annotation
Function Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron. {ECO:0000269PubMed:15794747, ECO:0000269PubMed:15863613, ECO:0000269PubMed:16950869, ECO:0000269PubMed:17065364, ECO:0000269PubMed:21653899}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:15794747, ECO:0000269PubMed:15863613, ECO:0000269PubMed:16950869}; Multi- pass membrane protein {ECO:0000269PubMed:15794747, ECO:0000269PubMed:15863613, ECO:0000269PubMed:16950869}. Note=Localized to the plasma membrane.
Disease Associations
Tissue Specificity Highly and transiently expressed during the early stage of adipocyte differentiation. Strongly expressed in liver, preadipocyte, duodenum and jejunum, moderately in brain, heart, skeletal muscle, spleen, pancreas, kidney and white adipose cells. Expression is almost undetectable in lung, testis and brown adipose cells. {ECO:0000269PubMed:15794747, ECO:0000269PubMed:15863613, ECO:0000269PubMed:16950869, ECO:0000269PubMed:17065364}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005385 zinc ion transmembrane transporter activity
GO:0015093 ferrous iron transmembrane transporter activity
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006826 iron ion transport
GO:0006829 zinc ion transport
GO:0006882 cellular zinc ion homeostasis
GO:0015684 ferrous iron transport
GO:0030001 metal ion transport
GO:0055085 transmembrane transport
GO:0071577 zinc ion transmembrane transport
GO:0071578 zinc ion transmembrane import
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:2384851
InterPro IPR003689 Zinc/iron permease
PFAM PF02535
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q75N73
PhosphoSite PhosphoSite-Q75N73
TrEMBL D3Z6P5
UniProt Splice Variant
Entrez Gene 213053
UniGene Mm.270647
RefSeq NP_001128624
MGI ID
MGI Symbol Slc39a14
OMIM
CCDS CCDS49536
HPRD
IMGT
EMBL AB177995 AC025669 AK122197 BC021530
GenPept AAH21530 BAC65479 BAD16742

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca