Version 5.4
Homo sapiens Protein: GALR1
Summary
InnateDB Protein IDBP-5337.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GALR1
Protein Name galanin receptor 1
Synonyms GALNR; GALNR1;
Species Homo sapiens
Ensembl Protein ENSP00000299727
InnateDB Gene IDBG-5335 (GALR1)
Protein Structure
UniProt Annotation
Function Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004966 galanin receptor activity
GO:0005515 protein binding
GO:0017046 peptide hormone binding
GO:0042923 neuropeptide binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0007586 digestion
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051464 positive regulation of cortisol secretion
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000405 Galanin receptor family
IPR000611 Neuropeptide Y receptor family
IPR003906 Galanin receptor 1
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019427 7TM GPCR, serpentine receptor class w (Srw)
PFAM PF00001
PF10320
PF10323
PF10324
PRINTS PR00237
PR00663
PR01012
PR01418
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P47211
PhosphoSite PhosphoSite-P47211
TrEMBL
UniProt Splice Variant
Entrez Gene 2587
UniGene Hs.272191
RefSeq NP_001471
HUGO HGNC:4132
OMIM 600377
CCDS CCDS12012
HPRD 02657
IMGT
EMBL AC100863 AY541036 BC095530 CH471117 L34339 U23854 U53511 U90658 U90659 U90660
GenPept AAA50767 AAB60356 AAC51936 AAC95397 AAH95530 AAS47032 EAW66603

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca