InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GALR1

Summary

InnateDB Gene

IDBG-5335.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GALR1

Gene Name

galanin receptor 1

Synonyms

GALNR; GALNR1

Species

Homo sapiens

Ensembl Gene

ENSG00000166573

Encoded Proteins

IDBP-5337

galanin receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:77250549-77277896

Strand

Forward strand

Band

q23

Transcripts

ENST00000299727	ENSP00000299727
ENST00000582943

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004966	galanin receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0042923	neuropeptide binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007586	digestion
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051464	positive regulation of cortisol secretion

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024553

View Gene Order

ENSBTAG00000021003

Not yet available

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

P47211

TrEMBL

UniProt Splice Variant

Entrez Gene

2587

UniGene

Hs.272191

RefSeq

NM_001480

HUGO

HGNC:4132

OMIM

600377

CCDS

CCDS12012

HPRD

IMGT

EMBL

AC100863 AY541036 BC095530 CH471117 L34339 U23854 U53511 U90658 U90659 U90660

GenPept

AAA50767 AAB60356 AAC51936 AAC95397 AAH95530 AAS47032 EAW66603

RNA Seq Atlas

2587