InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Satb1

Summary

InnateDB Protein

IDBP-533753.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Satb1

Protein Name

special AT-rich sequence binding protein 1

Synonyms

2610306G12Rik; AW413156;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119842

InnateDB Gene

IDBG-190608 (Satb1)

Protein Structure

UniProt Annotation

Function

Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis (By similarity). Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold- associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin- loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. {ECO:0000250, ECO:0000269PubMed:10716941, ECO:0000269PubMed:11463840, ECO:0000269PubMed:12692553, ECO:0000269PubMed:15814699, ECO:0000269PubMed:17057718, ECO:0000269PubMed:18722016, ECO:0000269PubMed:19103759, ECO:0000269PubMed:19386260, ECO:0000269PubMed:9271405}.

Subcellular Localization

Nucleus. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs) (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Mainly expressed in thymus, spleen, and lymph nodes with a lower level observed in the brain. {ECO:0000269PubMed:15814699}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006325	chromatin organization
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008544	epidermis development
GO:0016571	histone methylation
GO:0042110	T cell activation
GO:0043367	CD4-positive, alpha-beta T cell differentiation
GO:0043374	CD8-positive, alpha-beta T cell differentiation
GO:0050798	activated T cell proliferation
GO:0060004	reflex