InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD79A

Summary

InnateDB Protein

IDBP-53377.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD79A

Protein Name

CD79a molecule, immunoglobulin-associated alpha

Synonyms

IGA; MB-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000221972

InnateDB Gene

IDBG-53375 (CD79A)

Protein Structure

UniProt Annotation

Function

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells. {ECO:0000269PubMed:8617796, ECO:0000269PubMed:9057631}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}.

Disease Associations

Agammaglobulinemia 3, autosomal recessive (AGM3) [MIM:613501]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269PubMed:10525050, ECO:0000269PubMed:11920841}. Note=The disease is caused by mutations affecting the gene represented in this entry. Two different mutations, one at the splice donor site of intron 2 and the other at the splice acceptor site for exon 3, have been identified. Both mutations give rise to a truncated protein.

Tissue Specificity

B-cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	15 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0030183	B cell differentiation
GO:0042100	B cell proliferation
GO:0042113	B cell activation
GO:0050853	B cell receptor signaling pathway

Cellular Component

GO:0005771	multivesicular body
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0019815	B cell receptor complex
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

InterPro

IPR003110 Phosphorylated immunoreceptor signalling ITAM
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF02189
PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00077
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P11912