InnateDB Protein
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IDBP-533817.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fzr1
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Protein Name
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fizzy/cell division cycle 20 related 1 (Drosophila)
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Synonyms
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AW108046; Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000114203
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InnateDB Gene
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IDBG-178312 (Fzr1)
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Protein Structure
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Function |
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis (By similarity). {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 82 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
82 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1926790
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InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
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PFAM |
PF00400
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PRINTS |
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
Q9R1K5
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PhosphoSite |
PhosphoSite-Q9R1K5
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TrEMBL |
Q3U3D4
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UniProt Splice Variant |
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Entrez Gene |
56371
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UniGene |
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RefSeq |
NP_062731
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MGI ID |
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MGI Symbol |
Fzr1
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OMIM |
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CCDS |
CCDS24057
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HPRD |
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IMGT |
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EMBL |
AF083809
AK154822
BC006616
CH466553
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GenPept |
AAD52029
AAH06616
BAE32854
EDL31417
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