Version 5.4
Mus musculus Gene: Fzr1
Summary
InnateDB Gene IDBG-178312.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fzr1
Gene Name fizzy/cell division cycle 20 related 1 (Drosophila)
Synonyms AW108046; Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1
Species Mus musculus
Ensembl Gene ENSMUSG00000020235
Encoded Proteins
IDBP-178314
fizzy/cell division cycle 20 related 1 (Drosophila)
IDBP-400700
fizzy/cell division cycle 20 related 1 (Drosophila)
IDBP-533817
fizzy/cell division cycle 20 related 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105325:
Gene Information
Type Protein coding
Genomic Location Chromosome 10:81366222-81378516
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000020457 ENSMUSP00000020457
ENSMUST00000118812 ENSMUSP00000112868
ENSMUST00000140901 ENSMUSP00000114203
ENSMUST00000138343
ENSMUST00000150824
ENSMUST00000127203
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 82 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 82 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0007067 mitotic nuclear division
GO:0008284 positive regulation of cell proliferation
GO:0016567 protein ubiquitination
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031572 G2 DNA damage checkpoint
GO:0040020 regulation of meiosis
GO:0045732 positive regulation of protein catabolic process
GO:0051488 activation of anaphase-promoting complex activity
GO:0070306 lens fiber cell differentiation
GO:0090344 negative regulation of cell aging
Cellular Component
GO:0005634 nucleus
GO:0005680 anaphase-promoting complex
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105325
View Gene Order
ENSBTAG00000031387
Not yet available
Pathways
NETPATH
REACTOME
REACT_215601
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_258062
Synthesis of DNA pathway
REACT_232628
DNA Replication pathway
REACT_262530
Switching of origins to a post-replicative state pathway
REACT_188957
Cellular responses to stress pathway
REACT_223647
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_204224
Phosphorylation of Emi1 pathway
REACT_188804
Cell Cycle pathway
REACT_244364
APC/C-mediated degradation of cell cycle proteins pathway
REACT_230745
Immune System pathway
REACT_203517
SCF-beta-TrCP mediated degradation of Emi1 pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_255479
Regulation of DNA replication pathway
REACT_188820
Cellular Senescence pathway
REACT_245230
Orc1 removal from chromatin pathway
REACT_246476
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_226135
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_225686
Autodegradation of Cdh1 by Cdh1:APC/C pathway
REACT_254995
Regulation of mitotic cell cycle pathway
REACT_236939
Removal of licensing factors from origins pathway
REACT_206033
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_229531
Adaptive Immune System pathway
REACT_253623
S Phase pathway
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04110
Cell cycle pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_6761
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_6785
Autodegradation of Cdh1 by Cdh1:APC/C pathway
REACT_6867
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
REACT_6821
SCF-beta-TrCP mediated degradation of Emi1 pathway
REACT_6875
Phosphorylation of Emi1 pathway
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_383
DNA Replication pathway
REACT_120956
Cellular responses to stress pathway
REACT_2014
Synthesis of DNA pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_899
S Phase pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_829
Regulation of DNA replication pathway
KEGG
hsa04110
Cell cycle pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
INOH
PID NCI
aurora_a_pathway
Aurora A signaling
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt Q9R1K5
TrEMBL Q3U3D4
UniProt Splice Variant
Entrez Gene 56371
UniGene
RefSeq NM_019757
OMIM
CCDS CCDS24057
HPRD
IMGT
MGI ID MGI:1926790
MGI Symbol Fzr1
EMBL AF083809 AK154822 BC006616 CH466553
GenPept AAD52029 AAH06616 BAE32854 EDL31417
RNA Seq Atlas 56371

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca