InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbxo6

Summary

InnateDB Protein

IDBP-533887.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxo6

Protein Name

F-box protein 6

Synonyms

AA408845; FBG2; Fbs2; Fbx6b; Fbxo6b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121379

InnateDB Gene

IDBG-204245 (Fbxo6)

Protein Structure

UniProt Annotation

Function

Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complexes. Involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity). Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex- type oligosaccharides. Also recognizes sulfated glycans. {ECO:0000250, ECO:0000269PubMed:12939278, ECO:0000269PubMed:15723043}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Present in liver and kidney (at protein level). Widely expressed. {ECO:0000269PubMed:12939278, ECO:0000269PubMed:18203720}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 135 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	135 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0006516	glycoprotein catabolic process
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0019005	SCF ubiquitin ligase complex

Protein Structure and Domains

PDB ID

MGI:1354743

InterPro

IPR001810 F-box domain
IPR007397 F-box associated (FBA) domain
IPR008979 Galactose-binding domain-like

PFAM

PF00646
PF12937
PF13013
PF04300

PRINTS

PIRSF

SMART

SM00256

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-Q9QZN4

TrEMBL

Z4YN00

UniProt Splice Variant

Entrez Gene

50762

UniGene

Mm.27445

RefSeq

MGI ID

MGI Symbol

Fbxo6

OMIM

CCDS

HPRD

IMGT

EMBL

AL606929

GenPept