InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fbxo6

Summary

InnateDB Gene

IDBG-204245.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxo6

Gene Name

F-box protein 6

Synonyms

AA408845; FBG2; Fbs2; Fbx6b; Fbxo6b

Species

Mus musculus

Ensembl Gene

ENSMUSG00000055401

Encoded Proteins

IDBP-204247

F-box protein 6

IDBP-204249

F-box protein 6

IDBP-270311

F-box protein 6

IDBP-533887

F-box protein 6

IDBP-541572

F-box protein 6

IDBP-539789

F-box protein 6

IDBP-535288

F-box protein 6

IDBP-628108

F-box protein 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116663:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:148145716-148152140

Strand

Reverse strand

Band

Transcripts

ENSMUST00000030858	ENSMUSP00000030858
ENSMUST00000056965	ENSMUSP00000062348
ENSMUST00000105706	ENSMUSP00000101331
ENSMUST00000152098	ENSMUSP00000121379
ENSMUST00000126615	ENSMUSP00000120801
ENSMUST00000134261	ENSMUSP00000123132
ENSMUST00000132083	ENSMUSP00000120431
ENSMUST00000168503	ENSMUSP00000130188

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 135 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	135 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0006281	DNA repair
GO:0006516	glycoprotein catabolic process
GO:0006986	response to unfolded protein
GO:0016567	protein ubiquitination
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process