InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Uxs1

Summary

InnateDB Protein

IDBP-534046.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Uxs1

Protein Name

UDP-glucuronate decarboxylase 1

Synonyms

1600025I13Rik; AI451869; AI649125; AW550562;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119939

InnateDB Gene

IDBG-149763 (Uxs1)

Protein Structure

UniProt Annotation

Function

Catalyzes the NAD-dependent decarboxylation of UDP- glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0008831	dTDP-4-dehydrorhamnose reductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042803	protein homodimerization activity
GO:0048040	UDP-glucuronate decarboxylase activity
GO:0050662	coenzyme binding
GO:0070403	NAD+ binding

Biological Process

GO:0006694	steroid biosynthetic process
GO:0033320	UDP-D-xylose biosynthetic process
GO:0044237	cellular metabolic process
GO:0045226	extracellular polysaccharide biosynthetic process
GO:0051262	protein tetramerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0016021	integral component of membrane
GO:0032580	Golgi cisterna membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1915133

InterPro

IPR001509 NAD-dependent epimerase/dehydratase
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR005913 dTDP-4-dehydrorhamnose reductase
IPR013120 Male sterility, NAD-binding
IPR021761 UDP-glucuronate decarboxylase N-terminal

PFAM

PF01370
PF01073
PF04321
PF07993
PF11803

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91XL3

PhosphoSite