InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Uxs1

Summary

InnateDB Gene

IDBG-149763.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Uxs1

Gene Name

UDP-glucuronate decarboxylase 1

Synonyms

1600025I13Rik; AI451869; AI649125; AW550562

Species

Mus musculus

Ensembl Gene

ENSMUSG00000057363

Encoded Proteins

IDBP-149765

UDP-glucuronate decarboxylase 1

IDBP-534046

UDP-glucuronate decarboxylase 1

IDBP-534501

UDP-glucuronate decarboxylase 1

IDBP-539015

UDP-glucuronate decarboxylase 1

IDBP-534469

UDP-glucuronate decarboxylase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115652:
This gene encodes an enyzme found in the perinuclear Golgi which catalyzes the synthesis of UDP-xylose used in glycosaminoglycan (GAG) synthesis on proteoglycans. The GAG chains are covalently attached to proteoglycans which participate in signaling pathways during development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:43746966-43827800

Strand

Reverse strand

Band

C1.1

Transcripts

ENSMUST00000076997	ENSMUSP00000076259
ENSMUST00000126008	ENSMUSP00000119939
ENSMUST00000139451	ENSMUSP00000118468
ENSMUST00000153317
ENSMUST00000136179
ENSMUST00000134860
ENSMUST00000136704	ENSMUSP00000121869
ENSMUST00000128261	ENSMUSP00000116719

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0008831	dTDP-4-dehydrorhamnose reductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042803	protein homodimerization activity
GO:0048040	UDP-glucuronate decarboxylase activity
GO:0050662	coenzyme binding
GO:0070403	NAD+ binding

Biological Process

GO:0006694	steroid biosynthetic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0033320	UDP-D-xylose biosynthetic process
GO:0044237	cellular metabolic process
GO:0045226	extracellular polysaccharide biosynthetic process
GO:0051262	protein tetramerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0016021	integral component of membrane
GO:0032580	Golgi cisterna membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000115652

View Gene Order

ENSBTAG00000005614

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00520

Amino sugar and nucleotide sugar metabolism pathway

mmu00500

Starch and sucrose metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00520

Amino sugar and nucleotide sugar metabolism pathway

hsa00500

Starch and sucrose metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.397456 Mm.431397

RefSeq

NM_026430 XM_006496227

OMIM

CCDS

CCDS35551

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas