InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plch2

Summary

InnateDB Protein

IDBP-534086.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plch2

Protein Name

phospholipase C, eta 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119864

InnateDB Gene

IDBG-207301 (Plch2)

Protein Structure

UniProt Annotation

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain. {ECO:0000269PubMed:15899900, ECO:0000269PubMed:16107206}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15899900}. Cell membrane {ECO:0000269PubMed:15899900}. Note=Localized predominantly at the plasma membrane.

Disease Associations

Tissue Specificity

Specifically detected in the brain, with higher level in cerebral cortex, olfactory bulb and hippocampus (at protein level). Expressed in the pyramidal cells of the hippocampus, but also in eye and lung. {ECO:0000269PubMed:15899900, ECO:0000269PubMed:16107206}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0008081	phosphoric diester hydrolase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction
GO:0046488	phosphatidylinositol metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:2443078

InterPro

IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001849 Pleckstrin homology domain
IPR002048 EF-hand domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM

PF00388
PF00169
PF00036
PF13202
PF13405
PF09279

PRINTS

PR00390

PIRSF

SMART

SM00148
SM00233
SM00054

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt