InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ikbke

Summary

InnateDB Protein

IDBP-534146.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ikbke

Protein Name

inhibitor of kappaB kinase epsilon

Synonyms

AW558201; IKK-i; IKKepsilon; Ikki;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124486

InnateDB Gene

IDBG-190983 (Ikbke)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 333 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	333 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004704	NF-kappaB-inducing kinase activity
GO:0005524	ATP binding
GO:0008384	IkappaB kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007252	I-kappaB phosphorylation
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0038061	NIK/NF-kappaB signaling
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005737	cytoplasm
GO:0016605	PML body

Protein Structure and Domains

PDB ID

MGI:1929612

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E0CY50

UniProt Splice Variant

Entrez Gene

56489

UniGene

Mm.386783

RefSeq

MGI ID

MGI Symbol

Ikbke

OMIM

CCDS

HPRD

IMGT

EMBL

AC109262

GenPept