InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dhrs3

Summary

InnateDB Protein

IDBP-534216.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dhrs3

Protein Name

dehydrogenase/reductase (SDR family) member 3

Synonyms

retSDR1; Rsdr1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122552

InnateDB Gene

IDBG-203127 (Dhrs3)

Protein Structure

UniProt Annotation

Function

Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

In the embryo, expressed in developing osteogenic and chondrogenic tissues of vertebra, rib, tooth and limb bud. {ECO:0000269PubMed:9853961}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004745	retinol dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0050662	coenzyme binding
GO:0052650	NADP-retinol dehydrogenase activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0003151	outflow tract morphogenesis
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0030278	regulation of ossification
GO:0042572	retinol metabolic process
GO:0044237	cellular metabolic process
GO:0048387	negative regulation of retinoic acid receptor signaling pathway
GO:0055114	oxidation-reduction process
GO:0060021	palate development
GO:0060349	bone morphogenesis
GO:0060411	cardiac septum morphogenesis

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1315215

InterPro

IPR001509 NAD-dependent epimerase/dehydratase
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR003869 Polysaccharide biosynthesis protein, CapD-like domain
IPR013968 Polyketide synthase, KR
IPR020842 Polyketide synthase/Fatty acid synthase, KR

PFAM

PF01370
PF00106
PF02719
PF08659

PRINTS

PR00080
PR00081

PIRSF

PIRSF000126

SMART

SM00822

TIGRFAMs

Post-translational Modifications

Modification

Cross-References