Version 5.4
Mus musculus Gene: Dhrs3
Summary
InnateDB Gene IDBG-203127.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dhrs3
Gene Name dehydrogenase/reductase (SDR family) member 3
Synonyms retSDR1; Rsdr1
Species Mus musculus
Ensembl Gene ENSMUSG00000066026
Encoded Proteins
IDBP-203129
dehydrogenase/reductase (SDR family) member 3
IDBP-270224
dehydrogenase/reductase (SDR family) member 3
IDBP-534216
dehydrogenase/reductase (SDR family) member 3
IDBP-535356
dehydrogenase/reductase (SDR family) member 3
IDBP-627770
dehydrogenase/reductase (SDR family) member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162496:
Short-chain dehydrogenases/reductases (SDRs), such as DHRS3, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:144892827-144928209
Strand Forward strand
Band E1
Transcripts
ENSMUST00000084184 ENSMUSP00000081200
ENSMUST00000105744 ENSMUSP00000101370
ENSMUST00000154208 ENSMUSP00000122552
ENSMUST00000128926
ENSMUST00000142808 ENSMUSP00000122578
ENSMUST00000133265
ENSMUST00000171001 ENSMUSP00000126154
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004745 retinol dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0050662 coenzyme binding
GO:0052650 NADP-retinol dehydrogenase activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0003151 outflow tract morphogenesis
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0030278 regulation of ossification
GO:0042572 retinol metabolic process
GO:0044237 cellular metabolic process
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0055114 oxidation-reduction process
GO:0060021 palate development
GO:0060349 bone morphogenesis
GO:0060411 cardiac septum morphogenesis
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000162496
View Gene Order
ENSBTAG00000024493
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_188260
Visual phototransduction pathway
REACT_196617
The retinoid cycle in cones (daylight vision) pathway
REACT_188257
Signal Transduction pathway
REACT_188255
Diseases associated with visual transduction pathway
KEGG
mmu00830
Retinol metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160083
The retinoid cycle in cones (daylight vision) pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_116125
Disease pathway
KEGG
hsa00830
Retinol metabolism pathway
INOH
PID NCI
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt O88876
TrEMBL B1ARS9 G5E8W9
UniProt Splice Variant
Entrez Gene 20148
UniGene Mm.14063
RefSeq NM_011303 NM_001172424 XM_006538678 XM_006538680 XM_006538681
OMIM
CCDS CCDS18912 CCDS51368
HPRD
IMGT
MGI ID MGI:1315215
MGI Symbol Dhrs3
EMBL AF061743 AF179238 AF179239 AF179240 AF179241 AK032958 AK151419 AL606909 AL626773 BC008980 BC010972 BC013540 CH466657 X95281
GenPept AAC63265 AAD55403 AAH08980 AAH10972 AAH13540 BAC28098 BAE30384 CAA64602 EDL29722
RNA Seq Atlas 20148

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca